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Molecular and cellular mechanisms of toxicity

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Published by CRC Press in Boca Raton .
Written in English


  • Molecular toxicology.,
  • Genetic toxicology.

Book details:

Edition Notes

Includes bibliographical references and index.

Statementedited by Francesco de Matteis, Lewis L. Smith.
ContributionsDe Matteis, Francesco, 1932-, Smith, Lewis L.
LC ClassificationsRA1220.3 .M65 1995
The Physical Object
Pagination224 p. :
Number of Pages224
ID Numbers
Open LibraryOL784652M
ISBN 100849392292
LC Control Number95016810

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Summary: This text considers aspects of molecular mechanisms and the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. Cellular and genetic aspects are also covered. Advances in Molecular and Cell Biology. Latest volume All volumes. Search in this book series. Mechanisms of Cell Toxicity. Edited by E. Edward Bittar. Vol Pages iii-xiii, () Download full volume. Previous volume. Next volume. Actions for selected chapters. New advances in molecular and cellular biology are allowing the dissection of mechanisms of cell death involving more subtle targets within the cell. Toxicology has been very important, not only in understanding the mechanisms, nature, and severity of toxicity and thereby helping in risk assessment, but toxicology has also played a very. The most complex path to toxicity involves more steps (Figure 3–1).First, the toxicant is delivered to its target or targets (step 1), interacting with endogenous target molecules (step 2a) or altering the environment (step 2b), triggering perturbations in cell function and/or structure (step 3), which initiate repair mechanisms at the molecular, cellular, and/or tissue levels (step 4).

In addition, new techniques are available to shed light on the mechanism of carcinogenesis in molecular terms. This conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis in September focused on the latest research in molecular mechanisms of metal-induced toxicity .   General mechanisms and specific molecular pathways of cadmium toxicity. The figure shows general mechanisms (gene regulation, apoptosis, autophagy, oxidative stress, and interaction with bioelements) along with the specific molecular pathways of Cd toxicity. Although presented hierarchically, none of the presented mechanisms can be favored. Search within book. Front Matter. Front Matter. Pages PDF. Cellular Specific Toxicity in the Lung. Lewis L. Smith, Benoit Nemery. Pages Organophosphate-induced Delayed Neuropathy: Anomalous Data Lead to Advances in Understanding. M. K. Johnson. Pages Molecular Mechanisms of Toxicity. Front Matter.   Molecular & Cellular Toxicology (MCT) is owned and published by the Korean Society of Toxicogenomics and Toxicoproteomics. It is published four times a year in a printed version.

  The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. However, the molecular and cellular mechanisms of SM action on male reproductive health and human sperm function are unclear. Excessive production of reactive oxygen species and the resulting oxidative stress is likely a significant mechanism of SM action, and could be associated with sperm DNA damage, membrane lipid peroxidation, reduced.   This module is focussed on understanding mechanisms of toxicity at the molecular level. Content of the course In a number of lectures and case-studies, molecular mechanisms underlying (organ-selective) toxicity and carcinogenicity will be discussed. Special emphasis will be on the role of drug metabolism and bio(in)activation in toxicology. Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins.